Organic anion-transporting polypeptides.

Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations.

Hepatic uptake of albumin-bound amphipathic organic cations has been suggested to be mediated by multispecific bile salt and organic anion transport systems. Therefore, we investigated whether the recently cloned rat organic anion transporting polypeptides 1 and 2 as well as the human organic anion transporting polypeptide might be involved in the hepatocellular uptake of bulky type II organic ...

Inhibition of Human Organic Anion Transporting Polypeptide (OATP) -1B1 and -1B3 by Tyrosine Kinase Inhibitors

Fruit juices as perpetrators of drug interactions: the role of organic anion-transporting polypeptides.

Grapefruit juice is widely recognized to cause important drug interactions via inhibition of CYP3A4, and a wider variety of fruit juices have been shown to inhibit influx transporters in enterocytes known as organic anion-transporting polypeptides (OATPs). Fruit juice coadministration significantly reduces the oral bioavailability of numerous important medicines relying on this anion transporte...

Molecular cloning, characterization and relevance for microcystin-kinetics of Organic anion transporting polypeptides in model and native fish species

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Membrane Protein Quantification by Peptide-Based Mass Spectrometry Approaches: Studies on the Organic Anion-Transporting Polypeptide Family

Abbreviations: ABC: Ammonium Bicarbonate; AQUA: Absolute Quantification; CV: Coefficient of Variation; DOC: Deoxycholate; DTT: Dithiothreitol; Gdn: Guanidine; IS: Internal Standard; MRM: Multiple Reaction Monitoring; OATP: Organic Anion-Transporting Polypeptide; PMAX: ProteaseMAXTM Surfactant; S.E.M: Standard Error of the Mean; SIL: Stable Isotope Label; SILAC: Stable Isotope Labeling by Amino ...

Characterization of an organic anion transport system in a placental cell line.

Transporters within the placenta play a crucial role in the distribution of nutrients and xenobiotics across the maternal-fetal interface. An organic anion transport system was identified on the apical membrane of the rat placenta cell line HRP-1, a model for the placenta barrier. The apical uptake of 3H-labeled organic anion estrone sulfate in HRP-1 cells was saturable (Km = 4.67 microM), temp...